“Without (PharmacoGenetics) testing, neither you nor your doctor knows exactly how you’ll react to the medication. It may not work for you, or you may have serious side effects such as bleeding. You might have to try different doses — or even different medications — before finding a treatment that works for you.
Pharmacogenomics speeds up that process. Before you take a single dose of medication, you can have a test to see how you’re likely to respond to the medication. “
~Mayo Clinic
John Chandler ~~~~~ 602.482.0017 ~~~~~ johnc@chandlersearch.net
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Dear Doctor,
Your patient, _________________________________, has requested a Pharmacogenetic Test, as a result of receiving information about its benefits. Pharmacogenetic tests provide the physician with any genetic factors that might adversely interact with current or future drugs prescribed to the patient. As you well know, the more drugs the patient is taking the more risk of adverse drug reaction.
Medicare covers this test with no deductible or copay and some insurance companies cover it as well, subject to their policy deductible and copay. As a courtesy and at no cost to you, we will get “pre-authorizations” for each of your patients.
The test only requires a buccal swab. There is a prepaid, overnight, FedEx envelope to send the specimen to our Lab. Once submitted, you will receive a comprehensive PharmD report with your patient’s test results. You will find this to be a comprehensive and yet simple report. Our Medical Directors are also available to you for consult at your convenience.
I will be pleased to make an appointment with you to discuss the test procedure and simplicity of activating this greatly needed test within your practice.
Contact John Chandler – 602.482.0017 – johnc@chandlersearch.net – PacTox Certified Rep #10894
What is Pharmacogenetic Testing (PGT)?
Pharmacogenetics is the study of how a person’s genetic makeup affects the metabolism of medications. Pharmacogenetic testing (PGT) detects normal and single nucleotide polymorphism (SNPs) in the alleles of genes and their associated enzymes. PGT results therefore predict a person’s ability to metabolize certain medications. PacTox currently provides testing services on a total of nine genes (CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, Factor II, Factor V Leiden, MTHFR, and VKORC1) to give physicians a broad scope of information.
Cytochrome P450 enzymes (CYPs) include a superfamily of 57 enzymes. Subfamilies 1-3 are responsible for 75% of all drug metabolism. PGT results on the CYP genes are reported as extensive metabolizers (EM), poor metabolizers (PM), intermediate metabolizers (IM), or ultra-rapid metabolizers (UM) for their varying degrees of drug metabolizing abilities. Extensive metabolizers have normal drug metabolism. Poor metabolizers have no or very low metabolism; intermediate metabolizers have reduced metabolism; and ultra-rapid metabolizers have higher-than-normal drug metabolism.
Pharmacogenetics testing can be particularly useful in:
- Chronic pain management
- Knowing a patient’s genotypes prior to prescribing pain and other medicine
- Minimizing debilitating side effects
- PGT testing can mean the difference between a treatment failure and a successful outcome.You will know the following critical information for your patient:
- Which medication will BEST work for your patient
- Which medication will NOT work for your patient“The right information – right drug – right dosage – right from the beginning.”
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